The centre, located at Darlington's Central Park, includes teaching, learning and collaboration spaces, laboratories and a computing suite.
It will support the Tees Valley region's bioscience sector, driving STEM skills and economic growth and partnering with private companies like Fujifilm Diosynth Biotechnologies and the Centre for Process Innovation.
Project managed by SNC-Lavalin’s Faithful+Gould business on behalf of Teesside University, the scheme has been completed on time and within budget after a year-long build programme.
Andrew Rapmund, Faithful+Gould’s project management lead for the centre, said: “We are proud to have been a pivotal part of this significant project for both the Tees Valley region and the bioscience sector across the UK.
“It will train our young people to become the scientists of the future and continue to drive forward the Tees Valley as a leader in research, science and innovation in the UK and the world. As a business who has had a presence in the Tees Valley for more than 50 years, we’re excited for the centre’s future.”
A programme of specialist equipment fit-out works has also been completed in readiness for the opening of the new campus later this year.
Darren Vipond, director of campus services at Teesside University, said: "We are delighted that this major construction milestone has now been completed.
"The National Horizons Centre will play an important role in growing the region’s economy and it’s fantastic to see that its construction has already led to the creation of a number of employment opportunities."
Tees Valley Mayor Ben Houchen said: "The new National Horizons Centre is one of the biggest investments we have made so far. Our rich history of innovation, research and development is set to continue thanks to this state-of-the-art facility in Darlington.
"Just a year ago, I was stood in an empty field and we were breaking ground on this world-class biosciences research facility - and now we’re seeing the results. I’m also delighted to see that local businesses and local apprentices have benefited from the construction phase."